4-Methylmethcathinone (Mephedrone): Neuropharmacological Effects of a Designer Stimulant of Abuse
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چکیده
منابع مشابه
4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse.
The designer stimulant 4-methylmethcathinone (mephedrone) is among the most popular of the derivatives of the naturally occurring psychostimulant cathinone. Mephedrone has been readily available for legal purchase both online and in some stores and has been promoted by aggressive Web-based marketing. Its abuse in many countries, including the United States, is a serious public health concern. O...
متن کامل1 Mephedrone ( 4 - methylmethcathinone ; ‘ meow meow ’ ) ; chemical , pharmacological and clinical
1: University of Hertfordshire, School of Pharmacy, Hatfield, UK 2: Hertfordshire Partnership Foundation Trust, Herftordshire, UK 3: International Centre for Drug Policy, St George‟s University of London, UK 4: King‟s College London, Department of Addictions, Institute of Psychiatry London, (UK) 5: LVR-Hospital Essen, University of Duisburg-Essen, Essen, Germany 6: Consorci Mar Parc de Salut Ba...
متن کاملMephedrone (4-Methylmethcathinone): Acute Behavioral Effects, Hyperthermic, and Pharmacokinetic Profile in Rats
Mephedrone (MEPH) is a synthetic cathinone derivative with effects that mimic MDMA and/or cocaine. Our study in male Wistar rats provides detailed investigations of MEPH's and its primary metabolite nor-mephedrone's (nor-MEPH) pharmacokinetics and bio-distribution to four different substrates (serum, brain, lungs, and liver), as well as comparative analysis of their effects on locomotion [open ...
متن کاملMephedrone (methylmethcathinone) in toxicology casework: a Northern Ireland perspective.
Mephedrone (4-methylmethcathinone) is the beta-keto analogue of 4-methylmethylamphetamine. Before its control in April 2010, it became popular as a legal high in the United Kingdom, displacing methylenedioxymethylamphetamine as the stimulant drug of choice. The drug has stimulant and psychoactive properties, and therefore has forensic significance in criminal and morbid toxicology. The purpose ...
متن کاملIdentification and characterization of an imidazolium by-product formed during the synthesis of 4-methylmethcathinone (mephedrone).
4-Methylmethcathinone (2-methylamino-1-(4-methylphenyl)propan-1-one, mephedrone) is a psychoactive substance that has been associated with recreational use worldwide. Analytical data related to mephedrone are abundantly available but the characterization of by-products obtained during organic synthesis remains to be explored. This study presents the identification of a 1,2,3,5-tetramethyl-4-(4-...
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Experimental Therapeutics
سال: 2011
ISSN: 0022-3565,1521-0103
DOI: 10.1124/jpet.111.184119